Redox Report

Redox response dynamics in neurological disorders: From pathogenesis to therapy

Neurological disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and other neurodegenerative and neuroinflammatory conditions, are a major global health challenge. Redox imbalance is increasingly recognized as an important contributor to their complex pathophysiology. Dysregulated production and removal of reactive species can alter redox signaling and promote lipid peroxidation, protein oxidation, and nucleic acid damage. These processes can disrupt neuronal and glial function, underscoring the need to define shared and disease-specific redox mechanisms.

The nervous system is particularly sensitive to redox disturbances because of its high energy demand, lipid-rich composition, and dependence on tightly regulated cell signaling. Redox changes may interact with mitochondrial dysfunction, neuroinflammation, impaired proteostasis, and synaptic alterations throughout disease development. Identifying reliable redox biomarkers and defining the roles of specific reactive species could support earlier detection and more precise interventions. Although broad antioxidant approaches have shown limited clinical success, mechanistically informed strategies targeting distinct redox pathways remain promising areas for investigation.

This Article Collection will examine redox responses across neurological disorders, with emphasis on underlying mechanisms and their diagnostic and therapeutic implications. We welcome studies using cellular and animal models, patient-derived samples, advanced imaging, biosensors, and omics technologies. Areas of interest include oxidative modifications, mitochondrial redox biology, neuroimmune interactions, metabolic and environmental influences, the gut–brain axis, sex-related differences, and emerging biomarkers or targeted therapies. Original research articles, reviews, and perspectives addressing both shared and disease-specific redox processes are encouraged.

Topics of Interest:

• Redox Signaling and Oxidative Stress in Neurological Disorders
• Redox Biomarkers for Neurological Disease Diagnosis and Progression
• Lipid Peroxidation and Oxidative Modifications of Biomolecules
• Omics Approaches to Neurological Redox Biology
• Cellular, Animal, and Patient-Derived Models of Redox Dysfunction
• Mitochondrial Dysfunction, Proteostasis, and Neuroinflammation
• Redox Mechanisms in Synaptic Dysfunction and Neuronal Loss
• Environmental, Metabolic, and Epigenetic Modifiers of Redox Responses
• Gut–Brain Axis and Sex-Related Differences in Neurological Redox Biology
• Targeted Antioxidant and Redox-Modulating Therapeutic Strategies

Keywords:

• Neurological Disorders
• Redox Signaling
• Antioxidant Therapy
• Omics Technologies
• Neurodegeneration and Neuroinflammation
• Biomarkers

Guest Advisors:

Dr. Mikaela Peglow Pinz holds a degree in Pharmacy from the Federal University of Pelotas (2016) and obtained both MSc (2018) and PhD (2021) degrees in Sciences, with a specialization in Biochemistry and Bioprospecting. Her academic work has focused on the pharmacological evaluation of selenium-based organic compounds, particularly their antioxidant properties in experimental models of Alzheimer’s disease. Currently, she is a postdoctoral researcher at the Department of Biochemistry, Institute of Chemistry, University of São Paulo, where she investigates the role of organic peroxides in redox signaling using advanced biosensor technologies in mammalian cells. She is also a member of the editorial board of the journal Redox Report. Further details can be found at: http://lattes.cnpq.br/5409361390945855

Prof. Dr. Renata Leivas de Oliveira holds a degree in Pharmacy from the Federal University of Pelotas (UFPel), Brazil (2017), and an MSc (2019) and PhD (2023) in Sciences from the Graduate Program in Biochemistry and Bioprospecting at UFPel. She also completed postdoctoral research in Biotechnology at UFPel (2026). She is currently a Professor at the Federal University of Pelotas, where she teaches in the Pharmacy program. Her research focuses on neuropsychiatric and neurodegenerative disorders, with particular emphasis on the role of the gut microbiota and the modulation of the microbiota–gut–brain axis. Her work aims to elucidate the mechanisms underlying the interactions between the gut microbiota and the central nervous system and to investigate potential therapeutic strategies for these disorders and their associated comorbidities. Further details about her academic background and research activities are available at: http://lattes.cnpq.br/1898414452881911

Dr. Karline da Costa Rodrigues graduated in Pharmacy from the Federal University of Pelotas (UFPel-2018), with experience in scientific initiation during graduation (2015-2018). She obtained a MSc degree (2018-2020) and a PhD degree (2020-2024) from the Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio) at UFPel. From April 2023 to March 2024, she carried out a sandwich doctorate at the University of Coimbra (UC), Portugal, in the laboratory "MitoXT - Mitochondrial Toxicology and Experimental Therapeutics". Throughout her academic career, she acquired extensive experience in experimental models with rats and mice, investigation of neurodegenerative and neuropsychiatric diseases, manipulation and differentiation of tissues, as well as work with cell cultures. Further details can be found at: http://lattes.cnpq.br/3934644844193604

Disclosure Statement: Guest Advisors have no conflicts of interest to disclose.

Please review the journal scope and author submission instructions prior to submitting a manuscript.

To submit your papers to this Article Collection, please:

1. Check "yes" for the question, "Are you submitting your paper for a specific special issue or article collection?"
2. Select the Article Collection "Redox response dynamics in neurological disorders: From pathogenesis to therapy" from the drop-down menu under the question, "Special Issue or Article Collection Name."

Please contact Changluan Zhou at changluan.zhou@taylorandfrancis.com with any queries and discount codes regarding this Article Collection.