International Journal of Nanomedicine

Nanoengineered Biomaterials for Functional Tissue Regeneration and Clinical Translation

Tissue regeneration requires biomaterials that do more than providing structural support; they must actively communicate with cells, tissues, and the immune system to guide healing and restore function. Recent advances in nanotechnology have enabled the development of nanoengineered biomaterials with tunable physicochemical, mechanical, biological, and therapeutic properties. These systems can mimic the hierarchical organization of native extracellular matrix, regulate cell adhesion and differentiation, deliver bioactive molecules, and modulate the local microenvironment. Progress in nanofibers, nanoparticles, nanocomposites, injectable hydrogels, self-assembling materials, bioinks, and biomimetic nanovesicles is creating new opportunities for the regeneration of bone, cartilage, skin, nerve, cardiovascular, and other tissues. This Article Collection will highlight emerging nanomedicine strategies that combine materials science, cellular engineering, drug delivery, and regenerative medicine.

The clinical repair of damaged or diseased tissues remains limited by inadequate vascularization, inflammation, infection, fibrosis, poor integration with host tissue, and the inability to reproduce the complex architecture of native organs. Nanoengineered biomaterials may address these challenges by providing spatially and temporally controlled delivery of growth factors, nucleic acids, small molecules, cells, and extracellular-vesicle-inspired therapeutics. In addition, immunomodulatory and stimuli-responsive materials can regulate the healing environment and promote functional rather than scar-mediated repair. However, important challenges remain, including reproducible manufacturing, long-term safety, biodegradation, sterilization, scalability, and translation from small-animal models to clinically relevant systems. Addressing these barriers is essential for developing safe, effective, and commercially viable regenerative nanomedicines. This Collection will encourage research that connects innovative material design with meaningful biological outcomes, robust preclinical validation, and realistic clinical translation.

This Article Collection will cover nanoengineered scaffolds, nano-fibrous / self-assembling biomaterials, injectable / stimuli-responsive hydrogels, nano composites, nanostructured implant surfaces, and hybrid materials for tissue regeneration. Topics of interest include controlled delivery of therapeutic agents, extracellular vesicle and exosome-mimetic systems, immunomodulatory biomaterials, vascularization, antimicrobial regeneration, 3D bioprinting, organoid / tissue-interface engineering, and biosensing approaches for monitoring repair. Studies addressing biomaterial synthesis, cell and molecular mechanisms, biodistribution, nanotoxicology, sterilization, regulatory considerations, and clinical translation are particularly encouraged. The Collection will welcome original research articles, reviews, systematic reviews, and expert perspectives that fit the scope and standards of the International Journal of Nanomedicine.

Please submit your manuscript through the Dovepress website.

Please contact Haoyang Yi (Commissioning Editor) at haoyang.yi@taylorandfrancis.com with any queries regarding this Article Collection.

Guest Advisor

Prof. Tapash Ranjan Rautray

Prof. Tapash Ranjan Rautray is the Professor and Head of the Biomaterials and Tissue Regeneration Division at the Centre of Excellence, Siksha ‘O’ Anusandhan University, India, where he has been working on development of biomedical implants, and on smart, nanoengineered biomaterials for orthopedic and dental applications, including polarized piezoelectric bioceramics, ion-implanted and nanotopographically patterned titanium, and composite scaffolds for bone regeneration. He has published over 120 journal articles (h-index 36), as well as numerous book chapters and two authored books on titanium surface modification and corrosion. He holds four patents, has led externally funded research projects as Principal Investigator, has graduated seven PhD scholars, and has been ranked among the world’s Top 2% Scientists (Stanford/Elsevier list, 2024-2026). He serves on the editorial boards of several international journals, and is well placed to guide this collection on nanoengineered biomaterials for functional tissue regeneration and clinical translation.